Exploiting RNA interference pathways has been highly successful in yeast and animal but has had limited success in bacteria. However Duke University researchers have been investigating a ‘DNA Intereference’ approach to apply to bacteria. This has numerous applications (most which have yet to be discovered ), some of the more obvious are making chlorine sensitive bacteria in our water supply sensitive again, metabolic engineering for use in drug and biofuel production allowing you refine bioproduction pathways and turning off antibiotic resistant genes. Overall, like eukaryotic RNA interference, it allows more flexibility in manipulating organisms, as opposed to gene deletions.
It will be interesting to see what commercial opportunities are generated from this new technology.